Their proposed solution is to downgrade Trafford's A&E unit and intensive care and end emergency surgery.
The big question is, does Greater Manchester still need all these hospitals?
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Under the new plan it would become a specialist centre for orthopaedic care.
The proposals for Trafford General do include developing some new services as well as closing others.
From the roof of the BBC's Salford headquarters you can get a feel for how close some of these hospitals are to each other.
Like many other small district general hospitals across England,Beats by dre, it must make some very tough choices if it is to survive.
Now the hospital is known as Trafford General, but its place in the history of the NHS hasn't changed.
Hospital managers say it is not getting enough patients through the doors.
And just four miles to the east is Manchester Royal Infirmary, part of another big teaching hospital.
There are at least 16 other hospitals across the region.
"We feel lives are going to be put at risk by the closure of an A&E department anf intensive care" says Matthew Finnegan, of the Save Trafford General Campaign.
In 1948,Scarpe Hogan, the then health secretary Nye Bevan visited Park Hospital in Trafford,Abercrombie, Manchester, to open what was the very first hospital in the new National Health Service.
Trafford General is part of a network of at least 19 hospitals in the Greater Manchester area.
By Dominic HughesHealth correspondent, BBC News
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Out-patient services would continue, as would procedures like x-rays and blood tests.
Together they look after a population of around 2.7 million people.
But in the local shopping centre, protesters are out to defend their local hospital from what they see as financially driven cuts.
About two miles to the north east is the big teaching hospital of Salford Royal.
Their financial situation depends on where their wealth is held.
The future,Moncler Jacken, though, is looking a lot less certain.
Too many hospitals?
"Local people are really worried about what's going to happen to them when they need these kind of services locally.
Dr Nigel Guest is a member of Trafford NHS,Beats headphones, the body that buys medical services for the local area and is proposing the changes at the hospital.
"They want to save money and that means patient care is the thing that is actually being cut
It is an issue thrown into sharp relief at Trafford General.
Trafford General is about five miles further over to the west.
The hospital is losing ?19m a year and was recently taken over by the Central Manchester NHS Foundation Trust.
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